Utech C I, Khatibnia U, Winter P F, Wulle K G
University of Illinois College of Medicine at Peoria 61606, USA.
Thyroid. 1995 Jun;5(3):185-93. doi: 10.1089/thy.1995.5.185.
The results of 39 patients with severe Graves' ophthalmopathy (GO), who were monitored by magnetic resonance imaging (MRI) and tonography before and after combined immunosuppressive treatment with cyclosporine and corticosteroids, are presented. A correlation was found between the decrease in T2 relaxation time of the superior, medial, and inferior rectus muscle (p < 0.01) and the response to the immunosuppressive treatment. Muscle thickness and intraocular pressure showed less improvement (p < 0.05). The infiltrative eye signs improved partially in correlation with the T2 relaxation time. By distinguishing inflammation of the extraorbital muscles from fibrosis, the T2 relaxation time can help to select patients that benefit from immunosuppressive treatment as well as to monitor the therapeutic effect.
本文呈现了39例重度格雷夫斯眼病（GO）患者在接受环孢素和皮质类固醇联合免疫抑制治疗前后，通过磁共振成像（MRI）和眼压描记法进行监测的结果。上直肌、内直肌和下直肌的T2弛豫时间缩短（p < 0.01）与免疫抑制治疗反应之间存在相关性。肌肉厚度和眼压改善程度较小（p < 0.05）。浸润性眼部体征与T2弛豫时间相关，部分得到改善。通过区分眶外肌炎症和纤维化，T2弛豫时间有助于选择能从免疫抑制治疗中获益的患者，并监测治疗效果。
