Naito Y, Okazawa H, Honjo I, Hirano S, Takahashi H, Shiomi Y, Hoji W, Kawano M, Ishizu K, Yonekura Y
Department of Otolaryngology, Kyoto University Faculty of Medicine, Japan.
Brain Res Cogn Brain Res. 1995 Jul;2(3):207-14. doi: 10.1016/0926-6410(95)90009-8.
Six postlingually deaf patients using multi-channel cochlear implants were examined by positron emission tomography (PET) using 15O-labeled water. Changes in regional cerebral blood flow (rCBF) were measured during different sound stimuli. The stimulation paradigms employed consisted of two sets of three different conditions; (1) no sound stimulation with the speech processor of the cochlear implant system switched off, (2) hearing white noise and (3) hearing sequential Japanese sentences. In the primary auditory area, the mean rCBF increase during noise stimulation was significantly greater on the side contralateral to the implant than on the ipsilateral side. Speech stimulation caused significantly greater rCBF increase compared with noise stimulation in the left immediate auditory association area (P < 0.01), the bilateral auditory association areas (P < 0.01), the posterior part of the bilateral inferior frontal gyri; the Broca's area (P < 0.01) and its right hemisphere homologue (P < 0.05). Activation of cortices related to verbal and non-verbal sound recognition was clearly demonstrated in the current subjects probably because complete silence was attained in the control condition.
对6名使用多通道人工耳蜗的语后聋患者采用15O标记水的正电子发射断层扫描（PET）进行检查。在不同声音刺激期间测量局部脑血流量（rCBF）的变化。所采用的刺激模式包括两组三种不同情况：（1）人工耳蜗系统的言语处理器关闭，无声音刺激；（2）听白噪声；（3）听连贯的日语句子。在初级听觉区，噪声刺激期间对侧的平均rCBF增加显著大于同侧。与噪声刺激相比，言语刺激在左侧紧邻听觉联合区（P < 0.01）、双侧听觉联合区（P < 0.01）、双侧额下回后部（布罗卡区，P < 0.01）及其右半球对应区域（P < 0.05）引起的rCBF增加显著更大。在当前受试者中清楚地显示了与言语和非言语声音识别相关的皮质激活，这可能是因为在对照条件下实现了完全安静。
