Campbell M J, Julious S A, Altman D G
Medical Statistics and Computing, University of Southampton, Southampton General Hospital.
BMJ. 1995 Oct 28;311(7013):1145-8. doi: 10.1136/bmj.311.7013.1145.
Sample size calculations are now mandatory for many research protocols, but the ones useful in common situations are not all easily accessible. This paper outlines the ways of calculating sample sizes in two group studies for binary, ordered categorical, and continuous outcomes. Formulas and worked examples are given. Maximum power is usually achieved by having equal numbers in the two groups. However, this is not always possible and calculations for unequal group sizes are given.
现在,许多研究方案都必须进行样本量计算,但在常见情况下有用的样本量计算方法并非都易于获取。本文概述了两组研究中针对二元、有序分类和连续结果计算样本量的方法。文中给出了公式和实例。通常两组人数相等时能达到最大检验效能。然而,这并非总是可行的,本文也给出了不等组样本量的计算方法。