[在贝米替尔影响下大鼠海马中致痫灶活性的变化]
[Changes in the activity of an epileptogenic focus in the rat hippocampus under the influence of bemitil].
作者信息
Mikhaĭlov I B, Sharf M Ia, Guzeva V I
出版信息
Eksp Klin Farmakol. 1995 Jul-Aug;58(4):12-3.
PMID:7580743
Abstract
Experiments performed on male rats with chronically implanted electrochemotrodes showed bemitil (12.5 and 25.0 mg/kg, intra-abdominally, 24 h prior to the locus creation) suppresses he pathological activity of (100 ED) epileptogenic locus induced by he sodium salt of penicillin in the hippocampus of the animals. Probable mechanisms of antiepileptic action of bemitil are considered.
摘要
对长期植入电化学电极的雄性大鼠进行的实验表明，贝米替尔（12.5和25.0毫克/千克，腹腔内给药，在病灶形成前24小时）可抑制青霉素钠盐在动物海马体中诱导产生的（100 ED）致痫病灶的病理活性。文中还探讨了贝米替尔抗癫痫作用的可能机制。
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