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[3-羟基吡啶类抗氧化剂对钴诱导病灶大鼠脑癫痫活动作用的电生理分析]

[An electrophysiological analysis of the action of an antioxidant of the 3-hydroxypyridine class on the cerebral epileptic activity in rats with a cobalt-induced focus].

作者信息

Aliev A N, Nerobkova L N, Voronina T A, Guseĭnov D Ia

出版信息

Farmakol Toksikol. 1990 Jan-Feb;53(1):20-2.

PMID:2109704
Abstract

In experiments on albino male rats with chronically implanted electrodes and an epileptogenic focus in the cortical sensomotor region it was shown that a derivative of 3-hydroxy-pyridine (2-ethyl-6-methyl-3-hydroxypyridine) possesses the pronounced antiepileptic effect. The effect of the agent is related to the functional state of the epileptic system whose resistance to pharmacotherapy depends on the power of the determinant focus.

摘要

在对白化雄性大鼠进行的实验中，这些大鼠长期植入电极且在皮质感觉运动区有癫痫病灶，结果表明3 - 羟基吡啶的一种衍生物（2 - 乙基 - 6 - 甲基 - 3 - 羟基吡啶）具有显著的抗癫痫作用。该药物的作用与癫痫系统的功能状态有关，而癫痫系统对药物治疗的抵抗力取决于决定性病灶的强度。

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1
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