Akopian V P, Kocharian A Zh, Topchian A V, Mirzoian N R
Eksp Klin Farmakol. 1995 Jul-Aug;58(4):23-5.
We studied the formation of vasomotor reflexes in hypokinesia and responses of the brain vessels to the action of GABA, hypotension, and hypercapnia. We found that the response of the brain vessels to GABA is delayed and the mechanisms which supported an adequate cerebral vasculation are distorted in hypotension. At the same time the disturbance of the reflectory reaction of the brain vessels in the course of forming the vasomotor reflexes and the absence of significant changes in response to GABA were noticed. The capability of GABA of inhibiting cerebral blood circulation arising in hypokinesia is shown.
我们研究了运动减退时血管运动反射的形成以及脑血管对γ-氨基丁酸(GABA)、低血压和高碳酸血症作用的反应。我们发现,脑血管对GABA的反应延迟,且在低血压状态下,维持适当脑血管循环的机制发生扭曲。同时,在血管运动反射形成过程中,观察到脑血管反射反应受到干扰,并且对GABA的反应未出现显著变化。研究显示了GABA抑制运动减退时脑血液循环的能力。