[使用γ-氨基丁酸能化合物和钙离子拮抗剂增强脑组织及其血管对极端影响的抵抗力的各个方面]
[Various aspects of increased resistance of the brain tissue and its vessels to extreme effects with the use of GABAergic compounds and Ca(2+) antagonists].
作者信息
Akopian V P, Melkonian K V, Samvelian V M, Shirinian E A, Mirzoian N R
机构信息
Erevan State Medical University, Armenia.
出版信息
Eksp Klin Farmakol. 1997 Sep-Oct;60(5):31-4.
PMID:9483402
Abstract
Experiments on rats showed that the morpho-functional state of the cerebral cortex microcirculatory bed suffers marked changes in different periods of hypokinesia. This was accompanied with obvious morphological changes in the brain, the development of brain edema in particular. It was found that the GABAergic agents which we used ranked below Ca-antagonists in antiedemic activity.
摘要
对大鼠的实验表明，在运动不足的不同阶段，大脑皮层微循环床的形态功能状态会发生显著变化。这伴随着大脑明显的形态学改变，尤其是脑水肿的发展。研究发现，我们所使用的GABA能药物在抗水肿活性方面低于钙拮抗剂。
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