[The stimulating effect of sialic acid on the processes of postradiation hemopoietic regeneration].

The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.0 g and then received N-ANA. A rise in erythropoietic activity production by bone marrow cells testified that elevation of hemopoiesis inducing microenvironment function is the base of stimulating effect of N-ANA on hemopoiesis.