Gaĭnutdinova D T, Lazareva D N, Speranskiĭ V V
Eksp Klin Farmakol. 1995 Jul-Aug;58(4):45-7.
The effect of pyrimidine, levamizol, and prodigiozan on the retarded hypersensitivity (RH) was studied on a model of adoptive transfer of the splenocytes from donors of different ages to young syngeneic recipients. Splenocytes from CBA and BALB/c suckers, receiving pyrimidine, activate the RH suppression. Levamizol and prodigiozan exert the same effect on BALB/c mice and inhibit the RH suppression in CBA mice. In mature CBA mice these preparations potentiate HST. The splenocytes from young and aged BALB/c donors receiving the preparations oppositely induce the RH recipients.
在将不同年龄供体的脾细胞过继转移给同基因年轻受体的模型上，研究了嘧啶、左旋咪唑和灵菌红素对迟发型超敏反应（RH）的影响。接受嘧啶的CBA和BALB/c幼鼠的脾细胞可激活RH抑制作用。左旋咪唑和灵菌红素对BALB/c小鼠有相同作用，并抑制CBA小鼠的RH抑制作用。在成熟CBA小鼠中，这些制剂可增强宿主抗移植物反应（HST）。接受这些制剂的年轻和老年BALB/c供体的脾细胞对RH受体有相反的诱导作用。
