儿童和青年内分泌系统与免疫系统的相互作用。
Interactions of the endocrine and immune systems in children and young adults.
作者信息
Papanicolaou D A, Chrousos G P
机构信息
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1862, USA.
出版信息
Curr Opin Pediatr. 1995 Aug;7(4):440-4. doi: 10.1097/00008480-199508000-00017.
In the recent past, we have seen novel information on the bidirectional interactions between the endocrine and immune systems. Thus, the central nervous system, through the hypothalamic-pituitary-adrenal axis and the peripheral autonomic and sensory systems, influences the quantity and the quality of the immune and inflammatory reactions. The latter, on the other hand, regulates the activity of the endocrine system by influencing its central and peripheral components. The reciprocal effects of the two systems on each other are adaptive and help survival of the self and species. Dysregulation or chronic alterations of the endocrine system can, however, increase the susceptibility of individuals to various diseases or lead to frank pathologic states.
最近，我们已经了解到关于内分泌系统和免疫系统之间双向相互作用的新信息。因此，中枢神经系统通过下丘脑 - 垂体 - 肾上腺轴以及外周自主神经系统和感觉系统，影响免疫和炎症反应的数量和质量。另一方面，后者通过影响内分泌系统的中枢和外周组成部分来调节其活性。这两个系统相互之间的互惠作用具有适应性，有助于个体自身和物种的生存。然而，内分泌系统的失调或慢性改变会增加个体对各种疾病的易感性，或导致明显的病理状态。
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