Dorion B J, Leung D Y
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
Pediatr Allergy Immunol. 1995 May;6(2):95-7. doi: 10.1111/j.1399-3038.1995.tb00266.x.
Peanuts are the most common cause of fatal and near-fatal food-induced anaphylaxis. The immune basis for susceptibility to peanut allergy is poorly understood. The current study examined the possibility that patients with peanut allergy, as compared to normals, use different T cell receptor variable beta regions (V beta) in the recognition of peanuts. The results demonstrate that stimulation of T cells from patients with peanut allergy results in the selective expansion of V beta 2+ T cells.
花生是食物诱发的致命和近乎致命过敏反应最常见的诱因。人们对花生过敏易感性的免疫基础了解甚少。当前的研究探讨了花生过敏患者与正常人相比，在识别花生时是否使用不同的T细胞受体可变β区（Vβ）的可能性。结果表明，刺激花生过敏患者的T细胞会导致Vβ2 + T细胞选择性扩增。
