Evans P J, Smith C, Mitchinson M J, Halliwell B
Pharmacology Group, King's College, London, UK.
Free Radic Res. 1995 Nov;23(5):465-9. doi: 10.3109/10715769509065267.
Oxidation of low density lipoproteins (LDL) in blood vessel walls plays a significant role in the development of atherosclerosis. LDL oxidation in vitro is greatly accelerated by the presence of "catalytic" iron or copper ions, which have already been shown to be present within advanced atherosclerotic lesions. We demonstrate here that mechanical damage to human arterial wall samples (both normal and early or intermediate atherosclerotic lesions) causes release of "catalytic" iron and copper ions, to an extent increasing with the damage. It may be that traumatic (e.g. during angioplasty) or other injury to the vessel wall contributes to the generation of metal ions that can facilitate LDL oxidation and other free radical reactions, so promoting atherosclerosis.
血管壁中低密度脂蛋白（LDL）的氧化在动脉粥样硬化的发展过程中起着重要作用。体外LDL氧化会因“催化”铁离子或铜离子的存在而大大加速，而这些离子已被证实在晚期动脉粥样硬化病变中存在。我们在此证明，对人体动脉壁样本（正常以及早期或中期动脉粥样硬化病变）的机械损伤会导致“催化”铁离子和铜离子的释放，且释放程度随损伤加剧而增加。可能是血管壁受到创伤（如血管成形术期间）或其他损伤会促使金属离子生成，这些金属离子会促进LDL氧化及其他自由基反应，从而推动动脉粥样硬化的发展。
