Altieri I, Pichini S, Pacifici R, Zuccaro P
Clinical Biochemistry Department, Istituto Superiore di Sanità, Roma, Italy.
J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):416-7. doi: 10.1016/0378-4347(95)00126-4.
A rapid and selective assay of clomipramine and its metabolite desmethylclomipramine in human plasma, based on high-performance liquid chromatography with UV detection has been developed. The compounds were subjected to solid-phase extraction, using Extrelut 1 cartridges. Recoveries ranged between 88-95% for clomipramine, and 75-80% for desmethylclomipramine. This method has been used for therapeutic monitoring of clomipramine and its metabolite in individuals treated with this drug.
基于高效液相色谱-紫外检测法，已开发出一种快速、选择性地测定人血浆中氯米帕明及其代谢物去甲氯米帕明的方法。使用Extrelut 1柱对化合物进行固相萃取。氯米帕明的回收率在88%-95%之间，去甲氯米帕明的回收率在75%-80%之间。该方法已用于接受此药物治疗的个体中氯米帕明及其代谢物的治疗监测。
