Schellenberg G D
Geriatric Research, Education and Clinical Center, Seattle Veterans Affairs Medical Center, Washington, USA.
Curr Opin Neurol. 1995 Aug;8(4):262-7. doi: 10.1097/00019052-199508000-00003.
Three genetic loci for Alzheimer's disease have been identified. These are the amyloid precursor gene on chromosome 21, a gene for early-onset autosomal dominant Alzheimer's disease on chromosome 14, and the risk-modifying gene APOE on chromosome 19. Additional Alzheimer's disease genes remain to be found. The genes identified by studying inherited forms of Alzheimer's disease are now being used to understand the initiating steps in the pathogenesis of the disease.
已确定了三个与阿尔茨海默病相关的基因位点。它们分别是位于21号染色体上的淀粉样前体基因、位于14号染色体上的早发性常染色体显性阿尔茨海默病基因，以及位于19号染色体上的风险调节基因APOE。其他与阿尔茨海默病相关的基因仍有待发现。通过研究阿尔茨海默病的遗传形式所确定的这些基因，目前正被用于了解该疾病发病机制的起始步骤。
