Adams M A, Thompson K E, Banting J D, Madigan M A, Friberg P
Department of Pharmacology and Toxicology, Queen's University, Kingston, Canada.
Blood Press Suppl. 1995;2:61-7.
Greater smooth muscle growth is an important feature of the changes in blood vessel morphology in hypertension. The increase in vessel wall thickness: lumen ratio resulting from vascular hypertrophy impacts directly on total peripheral vascular resistance thereby influencing the severity of hypertension. The roles played by mechanical forces, vasoactive substances, growth factors and endocrine hormones in mediating hypertrophic vascular growth responses in vivo are currently under investigation. Here we review our current research aimed at: (a) defining the roles in vivo, of the renin-angiotensin system (RAS) and sympathetic nervous system (SNS), in the development of cardiovascular hypertrophy; (b) defining the importance of endogenous vasodilator systems, in particular, the ability of nitric oxide to inhibit trophic responses induced by the RAS and SNS and (c) examining whether trophic stimulation via the two neurohumoral systems as well as the antitrophic activity of the vasodilator systems is in part dependent on changes in blood pressure. In these studies the obligatory enzyme ornithine decarboxylase has proved to be a useful marker of ongoing hypertrophic cardiovascular growth.
平滑肌过度生长是高血压血管形态变化的一个重要特征。血管壁增厚与管腔比值的增加源于血管肥大，这直接影响总外周血管阻力，从而影响高血压的严重程度。机械力、血管活性物质、生长因子和内分泌激素在介导体内肥厚性血管生长反应中所起的作用目前正在研究中。在此，我们综述了我们目前的研究，旨在：（a）确定肾素-血管紧张素系统（RAS）和交感神经系统（SNS）在心血管肥大发展过程中的体内作用；（b）确定内源性血管舒张系统的重要性，特别是一氧化氮抑制RAS和SNS诱导的营养反应的能力；以及（c）研究通过这两个神经体液系统的营养刺激以及血管舒张系统的抗营养活性是否部分取决于血压变化。在这些研究中，鸟氨酸脱羧酶这一必需酶已被证明是正在进行的肥厚性心血管生长的一个有用标志物。
