Horner K C, Guilhaume A
INSERM XR229 and Université Bordeaux II, Hôpital Pellegrin, France.
Eur J Neurosci. 1995 Jun 1;7(6):1305-12. doi: 10.1111/j.1460-9568.1995.tb01121.x.
Transmission electron microscopy of the cochlear organ of Corti in experimental endolymphatic hydrops revealed two principal features. Starting 1 month after induction of hydrops, osmiophilic inclusions thought to represent lipofuscin accumulation were frequently observed in the subcuticular cytoplasm of the outer hair cells along the length of the cochlea. Starting 3 months after induction of hydrops the efferent terminals on the outer hair cells appeared to be vacuolated. These data suggest that oxidative insult is likely to contribute to the pathology associated with endolymphatic hydrops and thus that free radical scavengers might be useful in the treatment of Menière's disease patients. In addition the early modification of the efferent innervation of the hydropic cochlea might underlie the known hypersensitivity to various insults, including noise stimulation, glycerol administration and hypoxia.
实验性内淋巴积水时柯蒂氏器的透射电子显微镜检查揭示了两个主要特征。在积水诱导1个月后，沿耳蜗全长，在外毛细胞的角质下细胞质中经常观察到被认为代表脂褐素积累的嗜锇性包涵体。在积水诱导3个月后，外毛细胞上的传出终末似乎出现空泡化。这些数据表明氧化损伤可能导致与内淋巴积水相关的病理变化，因此自由基清除剂可能对梅尼埃病患者的治疗有用。此外，积水耳蜗传出神经支配的早期改变可能是已知的对包括噪声刺激、甘油给药和缺氧在内的各种损伤超敏反应的基础。
