Plotkin V Ia, Rebrov B A
Med Tr Prom Ekol. 1995(6):15-7.
Radioimmune assay determined serum renin activity, serum aldosterone level and its excretion with urine, amounts of thromboxane A2 (TxA2), prostacyclins PgI2 and PgF2a in urine of 76 apparently healthy miners before and after the working shift. Conventional techniques were used for estimation of blood and urine electrolytes and creatinine. In this connection activity of renin-angiotensin-aldosterone system (RAAS) in the miners before and after the work appeared to depend on the age and the length of service, to reach the maximum at the age of 31-40 and at 11-15 years of the service. Afterwards the activity lowered. The miners older than 41 had RAAS response decreased or absent after the work. Ratio TxA2 PgI2 remained unchanged in the miners over age of 41, whereas in the younger miners the ratio considerably decreased during the work.
采用放射免疫分析法测定了76名身体健康的矿工在轮班前、后的血清肾素活性、血清醛固酮水平及其尿排泄量、尿中血栓素A2（TxA2）、前列环素PgI2和PgF2a的含量。采用传统技术测定血液和尿液中的电解质及肌酐。在这方面，矿工工作前后肾素 - 血管紧张素 - 醛固酮系统（RAAS）的活性似乎取决于年龄和工龄，在31 - 40岁及工龄11 - 15年时达到最高值。之后活性降低。41岁以上的矿工工作后RAAS反应减弱或消失。41岁以上矿工的TxA2/PgI2比值保持不变，而年轻矿工在工作期间该比值显著降低。
