Maize J C, Snider R L
Department of Dermatology, Medical University of South Carolina, Charleston 29425-0001, USA.
Dermatol Surg. 1995 Nov;21(11):960-2. doi: 10.1111/j.1524-4725.1995.tb00533.x.
Seborrheic keratoses (SKs) can be seen in association with cancers.
Our study was designed to demonstrate the occurrence of concomitant SKs and nonmelanoma skin cancers, as well as to correlate their histological types and clinical locations. The study was not intended to be an epidemiologic survey.
We prospectively collected 108 completely excised SKs, examined them microscopically, categorized them, and correlated the clinical site, histological type, and determined the incidence of concomitant malignancy.
Of the 108 SKs studied, 71 were acanthotic, 27 hyperkeratotic, and 10 reticulated. The incidence of associated nonmelanoma cancers was 4.6%. All malignancies were squamous cell carcinomas and were on sun-exposed skin. Three of the five malignancies arose in conjunction with reticulated SKs.
The incidence of nonmelanoma skin cancer in association with SKs may be greater than previously reported, particularly in SKs situated on photo damaged skin and of the reticulated type. SKs that have undergone recent growth or other clinical change should be biopsied and all SKs that are removed should be examined histologically.
脂溢性角化病（SKs）可与癌症相关。
我们的研究旨在证明SKs与非黑色素瘤皮肤癌同时出现的情况，以及将它们的组织学类型和临床部位相互关联。该研究并非旨在进行流行病学调查。
我们前瞻性地收集了108个完全切除的SKs，进行显微镜检查，对其进行分类，并将临床部位、组织学类型相互关联，确定同时存在恶性肿瘤的发生率。
在研究的108个SKs中，71个为棘层肥厚型，27个为角化过度型，10个为网状型。相关非黑色素瘤癌症的发生率为4.6%。所有恶性肿瘤均为鳞状细胞癌，且位于阳光暴露部位的皮肤。5例恶性肿瘤中有3例与网状SKs同时出现。
与SKs相关的非黑色素瘤皮肤癌的发生率可能高于先前报道，特别是位于光损伤皮肤且为网状类型的SKs。近期有生长或其他临床变化的SKs应进行活检，所有切除的SKs均应进行组织学检查。
