Sloan J B, Jaworsky C
Department of Dermatology, University of Pennsylvania, Philadelphia.
J Dermatol Surg Oncol. 1993 May;19(5):413-6. doi: 10.1111/j.1524-4725.1993.tb00367.x.
Seborrheic keratoses have on rare occasion been reported to undergo malignant transformation.
Our purpose was to examine the incidence and distribution of squamous cell carcinomas (SCCs) in situ arising in clinically banal-appearing seborrheic keratoses.
We prospectively selected such cases over a 6-month period of time from routinely accessioned specimens to a dermatopathology service.
We found 1.4% of clinically diagnosed seborrheic keratoses to be SCCs in situ. These lesions were more common in elderly persons and were more likely to occur on the head and neck, suggesting the role of cumulative sun damage in the transformation of such lesions.
Malignant transformation of seborrheic keratoses, although rare, appears to occur more frequently in the elderly on the head and neck. Because this change is not necessarily accompanied by clinically discernable changes, more careful scrutiny of such lesions may be of therapeutic rather than cosmetic significance in this population.
脂溢性角化病罕见情况下会发生恶变。
我们旨在研究临床外观平淡的脂溢性角化病中原位鳞状细胞癌（SCC）的发生率和分布情况。
我们在6个月的时间里，从常规接收的皮肤病理学标本中前瞻性地挑选出此类病例。
我们发现临床诊断的脂溢性角化病中有1.4%为原位SCC。这些病变在老年人中更为常见，且更易发生于头颈部，提示累积的阳光损伤在这类病变转变过程中的作用。
脂溢性角化病的恶变虽然罕见，但似乎在老年人的头颈部更常发生。由于这种变化不一定伴有临床可察觉的改变，因此对这类病变进行更仔细的检查在该人群中可能具有治疗意义而非美容意义。
