Asanuma N, Nomura H
Department of Oral Physiology, Matsumoto Dental College, Shiojiri, Japan.
Chem Senses. 1995 Apr;20(2):231-7. doi: 10.1093/chemse/20.2.231.
Guanylyl cyclase activity was cytochemically demonstrated in rabbit foliate taste buds. The enzymatic activity was localized in the apical portion (microvilli and neck) of taste bud cells. Especially strong activity was observed on the microvillous membrane of type I (dark) cells and often on a blunt process of type III cells. The microvilli of type II (light) cells showed weak enzymatic activity. Considering that the apical portion of taste cells is a likely site of interaction between taste stimuli and the cells, the results support the idea that cyclic GMP is involved in taste transduction.
在兔叶状味蕾中通过细胞化学方法证实了鸟苷酸环化酶活性。该酶活性定位于味蕾细胞的顶端部分（微绒毛和颈部）。在I型（暗）细胞的微绒毛膜上观察到特别强的活性，并且在III型细胞的钝突上也经常观察到。II型（亮）细胞的微绒毛显示出较弱的酶活性。鉴于味觉细胞的顶端部分可能是味觉刺激与细胞相互作用的部位，这些结果支持环磷酸鸟苷参与味觉转导的观点。
