尿中B族链球菌抗原检测作为新生儿败血症筛查方法的失败情况。
Failure of the urinary group B streptococcal antigen test as a screen for neonatal sepsis.
作者信息
Williamson M, Fraser S H, Tilse M
机构信息
Department of Microbiology, Master Misericordiae Public Hospitals, South Brisbane, Australia.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Sep;73(2):F109-11. doi: 10.1136/fn.73.2.f109.
The accuracy of the urinary group B streptococcal antigen latex agglutination (LA) test for screening infants at risk of group B streptococcal (GBS) sepsis in the first 24 hours of life was prospectively studied in 236 infants for six months. Infection with GBS was defined by a positive blood culture while colonisation was defined by GBS cultured from any other site. The combination of infection and colonisation was used as the gold standard for the LA test. Although the LA test had a sensitivity of 90%, the specificity was only 70%, the positive predictive value 12% and the false positive rate 30%. The overall accuracy was only 71%. The LA test was unable to predict GBS sepsis in infants at risk of the disease. The false positive rate was unacceptably high and could not be potentially accounted for in 11 infants. However, a negative test was useful in excluding GBS disease.
对236例婴儿进行了为期6个月的前瞻性研究，以评估尿B族链球菌抗原乳胶凝集（LA）试验在出生后24小时内筛查有B族链球菌（GBS）败血症风险婴儿的准确性。GBS感染定义为血培养阳性，而定殖则定义为从任何其他部位培养出GBS。感染和定殖的组合用作LA试验的金标准。尽管LA试验的敏感性为90%，但特异性仅为70%，阳性预测值为12%，假阳性率为30%。总体准确率仅为71%。LA试验无法预测有该疾病风险的婴儿的GBS败血症。假阳性率高得令人无法接受，并且在11例婴儿中无法潜在地解释其原因。然而，阴性试验有助于排除GBS疾病。
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