Friston K J, Frith C D
MRC Cyclotron Unit, Hammersmith Hospital, London, England.
Clin Neurosci. 1995;3(2):89-97.
We review the evidence of pathophysiological changes in the prefrontal and temporal cortices of schizophrenic subjects and of abnormal integration of the physiological dynamics in these two regions. The argument we develop is that some schizophrenic phenomena are best understood in terms of abnormal interactions between different areas, not only at the levels of physiology and functional anatomy, but at the level of cognitive and sensorimotor functioning. We discuss recent functional imaging evidence suggesting abnormal prefronto-temporal interactions in relation to a psychological analysis of experiential symptoms in schizophrenia. Cortico-cortical interactions have been assessed in terms of functional connectivity and eigenimages, using time series of neurophysiological data obtained with positron emission tomography. The results of these analyses suggest that there is a profound disruption of large-scale prefronto-temporal interactions in schizophrenia. These disruptions are particularly relevant if one considers that many positive symptoms of schizophrenia reflect a failure to integrate intrinsically generated behaviour and concurrent perception.
我们回顾了有关精神分裂症患者前额叶和颞叶皮质病理生理变化的证据，以及这两个区域生理动力学异常整合的证据。我们提出的观点是，某些精神分裂症现象最好从不同区域之间的异常相互作用来理解，不仅在生理和功能解剖层面，而且在认知和感觉运动功能层面。我们讨论了最近的功能成像证据，这些证据表明，与精神分裂症体验性症状的心理分析相关的前额叶-颞叶相互作用异常。利用正电子发射断层扫描获得的神经生理数据的时间序列，从功能连接性和特征图像方面评估了皮质-皮质相互作用。这些分析结果表明，精神分裂症患者存在大规模前额叶-颞叶相互作用的严重破坏。如果考虑到精神分裂症的许多阳性症状反映了内在产生的行为与同时发生的感知未能整合，那么这些破坏就尤为相关。
