Morgan M S, Arlian L G, Vyszenski-Moher D L, Deyo J, Kawabata T, Fernandez-Caldas E
Department of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Ann Allergy Asthma Immunol. 1995 Oct;75(4):351-9.
English plantain (Plantago lanceolata) weed pollen and psyllium (Plantago ovata) husk dust are inhalant allergens. Because of the phylogenetic relationship between these plant species, cross-allergenicity has been a concern.
The purpose of this study was to investigate the possible cross-allergenicity of plantain and psyllium.
Homologous and heterologous crossed immunoelectrophoresis (CIE) were performed using a commercial English plantain pollen extract and an extract of psyllium seed embryo. Crossed radioimmunoelectrophoresis (CRIE) was performed using sera from subjects who were RAST positive only to plantain (group A), RAST positive only to psyllium (group B), RAST positive to both plantain and psyllium (group C), or RAST negative to both (group D).
All of the group A plantain subjects showed IgE binding to at least one of the six plantain allergens in homologous plantain CRIEs while only one of the sera from the group B subjects reacted very weakly to these plantain allergens. In homologous psyllium CRIE, all group B subjects showed pronounced IgE binding to 2 to 7 of the seven psyllium allergens. Several of the plantain subjects demonstrated only very weak binding to psyllium allergens. Heterologous CRIEs demonstrated little relevant IgE binding.
These results indicate that there is little cross-allergenicity between psyllium husk and English plantain pollen.
英国车前草（窄叶车前）杂草花粉和亚麻籽车前（卵叶车前）果壳粉尘是吸入性过敏原。由于这些植物物种之间的系统发育关系，交叉变应原性一直是人们关注的问题。
本研究的目的是调查车前草和亚麻籽车前之间可能存在的交叉变应原性。
使用市售的英国车前草花粉提取物和亚麻籽车前种子胚提取物进行同源和异源交叉免疫电泳（CIE）。使用仅对车前草RAST阳性的受试者（A组）、仅对亚麻籽车前RAST阳性的受试者（B组）、对车前草和亚麻籽车前均RAST阳性的受试者（C组）或对两者均RAST阴性的受试者（D组）的血清进行交叉放射免疫电泳（CRIE）。
在同源车前草CRIE中，所有A组车前草受试者均显示IgE与六种车前草过敏原中的至少一种结合，而B组受试者中只有一份血清对这些车前草过敏原反应非常微弱。在同源亚麻籽车前CRIE中，所有B组受试者均显示IgE与七种亚麻籽车前过敏原中的2至7种有明显结合。一些车前草受试者对亚麻籽车前过敏原的结合非常微弱。异源CRIE显示几乎没有相关的IgE结合。
这些结果表明，亚麻籽车前果壳和英国车前草花粉之间几乎没有交叉变应原性。
