Gallagher H J, Daly J M
Hospital of the University of Pennsylvania, Philadelphia, USA.
Curr Opin Gen Surg. 1993:92-104.
Improvements in surgical management and intensive care therapy have enabled many patients to initially survive severe life-threatening trauma or major surgical procedures only to die after delayed bouts of sepsis. This paper reviews literature published within the past year on the effects of nutrient substitution on malnutrition, injury, and the host immune response. Topics discussed include immunodeficiencies in trauma and malnutrition, immunomodulation by nutrition, and parenteral versus enteral nutrition. We also discuss the roles of arginine, glutamine, omega-3 fatty acids, and dietary nucleotides in the host immune response.
外科治疗和重症监护疗法的改进使许多患者最初能够从严重的危及生命的创伤或重大外科手术中存活下来，但却在延迟性脓毒症发作后死亡。本文回顾了过去一年发表的关于营养替代对营养不良、损伤和宿主免疫反应影响的文献。讨论的主题包括创伤和营养不良中的免疫缺陷、营养的免疫调节以及肠外营养与肠内营养。我们还讨论了精氨酸、谷氨酰胺、ω-3脂肪酸和膳食核苷酸在宿主免疫反应中的作用。
