Skrzypczak J
Department of Reproduction, Institute of Obstetrics and Gynecology, Poznań Academy of Medicine, Poznań/Poland.
Exp Clin Endocrinol Diabetes. 1995;103(4):228-32. doi: 10.1055/s-0029-1211355.
The aim of the study was to see the function of follicular cells collected from ovaries of women suffering from endometriosis. The material was granulosa cells taken from 11 patients operated on 3rd and 4th degree of endometriosis. Antral granulosa cells were harvested from 34 medium-size (5-10 mm in diameter) follicles located on the cysts' walls or in the cysts' vicinity. Using the culture method, morphology and steroid secretion was estimated. Morphological properties of the cells in the culture did not differ significantly from that of healthy ones. All cells formed a monolayer and achieved different degrees of luteinization. Steroidogenesis of these granulosa cells was defected, particularly in the production of progesterone and testosterone.
该研究的目的是观察从患有子宫内膜异位症的女性卵巢中收集的卵泡细胞的功能。研究材料是取自11例接受3期和4期子宫内膜异位症手术患者的颗粒细胞。从位于囊肿壁或囊肿附近的34个中等大小（直径5-10毫米）卵泡中收获窦状颗粒细胞。采用培养方法评估细胞形态和类固醇分泌情况。培养细胞的形态学特性与健康细胞相比无显著差异。所有细胞均形成单层并达到不同程度的黄素化。这些颗粒细胞的类固醇生成存在缺陷，尤其是在孕酮和睾酮的产生方面。
