血清中对乙酰氨基酚的痕量测定。
Trace determination of acetaminophen in serum.
作者信息
Miner D J, Kissinger P T
出版信息
J Pharm Sci. 1979 Jan;68(1):96-7. doi: 10.1002/jps.2600680130.
PMID:758475
Abstract
A simple and accurate method for measuring acetaminophen in serum was developed using liquid chromatography with electrochemical detection. Acetaminophen can be quantitated in 100 microliter of serum over the range of 20 ng/ml--20 microgram/ml. The method is linear (r = 0.9997) and reproducible (RSD = 3.0% at 2 microgram/ml, RSD = 5.1% at 200 ng/ml, n = 6). An internal standard (N-propionyl-p-aminophenol) is used, and a single extraction is performed.
摘要
采用液相色谱-电化学检测法开发了一种简单准确的血清中对乙酰氨基酚测量方法。在20 ng/ml至20 μg/ml范围内，可对100微升血清中的对乙酰氨基酚进行定量。该方法呈线性（r = 0.9997）且具有可重复性（2 μg/ml时RSD = 3.0%，200 ng/ml时RSD = 5.1%，n = 6）。使用内标（N-丙酰基-对氨基苯酚），并进行单次萃取。
Zotero 插件