Korduba C A, Petruzzi R F
J Pharm Sci. 1984 Jan;73(1):117-9. doi: 10.1002/jps.2600730132.
A method is described for the rapid, sensitive, and precise quantitation of acetaminophen in human plasma. The assay involved a single acetonitrile extraction and high-performance liquid chromatographic analysis using a reverse-phase column, with a mobile phase of methanol and water. The limit of quantitation of acetaminophen by this method was 8 ng/mL; only 0.1 mL of the plasma sample was required for the determination. N-Propionyl-p-aminophenol was used as the internal standard.
本文描述了一种用于快速、灵敏且精确地定量测定人血浆中对乙酰氨基酚的方法。该测定方法包括单次乙腈萃取以及使用反相柱的高效液相色谱分析，流动相为甲醇和水。此方法对乙酰氨基酚的定量限为8 ng/mL；测定仅需0.1 mL血浆样品。使用N-丙酰基-对氨基苯酚作为内标。
