Muñoz-Torres M, Jódar E, Quesada M, Escobar-Jiménez F
Endocrinology Division (Cátedra de Medicina Interna I), Hospital Universitario, Granada, Spain.
Calcif Tissue Int. 1995 Aug;57(2):94-6. doi: 10.1007/BF00298426.
The response of bone mass to long-term treatment with estrogen and progesterone in patients with complete androgen-insensitivity syndrome (AIS) is unknown. We report a 17-year-old female patient (karyotype 46 X, Y) with AIS studied during a 4-year period. Bone mineral density (BMD) measured by dual X-ray absorptiometry in lumbar spine and proximal femur was sharply reduced at the initial visit; and remained unchanged during long-term follow-up on hormone replacement therapy with estrogens and progestin. Bone metabolism markers were all in the normal range. The lack of significant increase in BMD highlights the importance of androgens on bone physiology that cannot be balanced in spite of an appropriate estrogenic milieu.
完全雄激素不敏感综合征（AIS）患者的骨量对雌激素和孕激素长期治疗的反应尚不清楚。我们报告了一名17岁的AIS女性患者（核型46，X，Y），对其进行了为期4年的研究。初次就诊时，通过双能X线吸收法测量的腰椎和股骨近端骨密度急剧降低；在接受雌激素和孕激素激素替代治疗的长期随访期间，骨密度保持不变。骨代谢标志物均在正常范围内。骨密度缺乏显著增加突出了雄激素对骨生理学的重要性，尽管有适当的雌激素环境，这种重要性仍无法得到平衡。
