Mizunuma H, Soda M, Okano H, Kagami I, Miyamoto S, Ohsawa M, Ibuki Y
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan.
Hum Reprod. 1998 Oct;13(1O):2816-8. doi: 10.1093/humrep/13.10.2816.
Changes in bone mineral density (BMD) after orchidectomy and after hormone replacement therapy were reported in two patients with complete androgen insensitivity syndrome (AIS). Diagnosis of AIS was made by clinical features and confirmed by the presence of 46,XY karyotype and the presence of testis component in the removed gonads. BMD at the lumbar spine and at three sites of the femur was measured by dual energy X-ray absorptiometry (DXA). The Z scores of the lumbar spine BMD before orchidectomy were -0.8 and -3.1, confirming that patients with AIS have low BMD and that androgen plays an important role in bone mineralization in 46,XY individuals. Castration reduced BMD, but treatment with daily doses of 1.25 mg of conjugated oestrogen and 10 mg of medroxyprogesterone acetate increased BMD. These results indicate that both oestrogen and androgen play an important role in balancing BMD in men.
报道了两名完全性雄激素不敏感综合征（AIS）患者在睾丸切除术后及激素替代治疗后的骨矿物质密度（BMD）变化。AIS的诊断依据临床特征，并通过46,XY核型以及切除性腺中存在睾丸成分得以证实。采用双能X线吸收法（DXA）测量腰椎和股骨三个部位的BMD。睾丸切除术前腰椎BMD的Z值分别为-0.8和-3.1，证实AIS患者的BMD较低，且雄激素在46,XY个体的骨矿化中起重要作用。去势降低了BMD，但每日服用1.25mg结合雌激素和10mg醋酸甲羟孕酮的治疗增加了BMD。这些结果表明雌激素和雄激素在男性BMD平衡中均起重要作用。
