Roberts J L, Hanifin J M
JAMA. 1979 Jan 19;241(3):275-6.
Ten patients with severe foot dermatitis were found to be highly allergic to innersole material prepared by Spenco Medical Corporation and used in Nike athletic shoes. Contact allergy testing showed sensitivity to ethyl butyl thiourea, a chemical accelerator in some neoprene (polychioroprene) rubber products. The dermatitis was recalcitrant and in many cases persisted long after discontinuance of wearing Nike shoes, raising the concern that traces of ethyl butyl thiorea or cross-reacting chemicals may be present in other footwear.
十名患有严重足部皮炎的患者被发现对斯潘科医疗公司生产并用于耐克运动鞋的鞋垫材料高度过敏。接触性过敏测试显示对乙基丁基硫脲敏感，乙基丁基硫脲是一些氯丁橡胶（聚氯丁二烯）橡胶产品中的一种化学促进剂。这种皮炎很难治疗，在许多情况下，即使停止穿耐克鞋后仍会持续很长时间，这引发了人们对其他鞋类中可能存在乙基丁基硫脲痕迹或交叉反应化学物质的担忧。
