Li J, Chang H W, Lai E, Parker E J, Vogt P K
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
Cancer Res. 1995 Dec 1;55(23):5540-4.
The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to the DNA-binding domain of the yeast GAL4 protein, both Qin proteins act as transcriptional repressors. The major transcriptional repression domain maps to the region of amino acids 252-395 of viral Qin.
逆转录病毒癌基因qin编码一种属于转录调节因子有翼螺旋家族的蛋白质。Qin蛋白定位于细胞核，并且与大鼠脑因子1（BF-1）结合相同的DNA共有序列。细胞Qin对DNA的亲和力比病毒Qin更高。单独或与酵母GAL4蛋白的DNA结合结构域融合时，两种Qin蛋白均作为转录抑制因子发挥作用。主要的转录抑制结构域定位于病毒Qin氨基酸252 - 395区域。
