Horackova M, Armour J A
Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, N.S., Canada.
Cardiovasc Res. 1995 Sep;30(3):326-35. doi: 10.1016/0008-6363(95)00105-0.
This review has focused on the putative effects that peripheral autonomic neurones exert on cardiac myocytes. Through data obtained by the use of in situ and in vitro models, the unique synaptology and chemical sensitivities of the various types of neurones in intrinsic cardiac and extracardiac intrathoracic ganglia are becoming evident. The intrathoracic nervous system acts as a distributive network, processing in a complex fashion information that arises not only from cardiac, vascular and pulmonary tissues but also from extrathoracic tissues, to maintain adequate cardiac function. In challenging the current understanding of cardiac regulation, this view provides novel opportunities to develop pharmacological and surgical strategies to manipulate cardiac function in disease states.
本综述聚焦于外周自主神经元对心肌细胞的假定作用。通过使用原位和体外模型获得的数据，心脏固有神经节和胸内心脏外神经节中各类神经元独特的突触学和化学敏感性正变得清晰。胸内神经系统作为一个分布网络，以复杂的方式处理不仅来自心脏、血管和肺组织，还来自胸外组织的信息，以维持适当的心脏功能。这一观点挑战了当前对心脏调节的理解，为开发在疾病状态下操纵心脏功能的药理学和手术策略提供了新的机会。
