Margarone J E, Liebow C, Hall R E, Braun R E, Weiner M
Department of Oral and Maxillofacial Surgery, State University of New York at Buffalo, USA.
Clin Pharmacol Ther. 1995 Oct;58(4):453-8. doi: 10.1016/0009-9236(95)90059-4.
This study compares the analgesic effects of two standard combinations (Empirin with codeine versus Mersyndol) and placebo as measured by crossover versus parallel-group design. The analgesic results obtained with three groups of 12 to 13 crossed over subjects with two extractions divided into six subgroups of five to seven subjects for each sequence were qualitatively the same and statistically at least as strong as those obtained by analysis of parallel groups of 38 to 42 extractions per group. By both methods the analgesics were statistically significantly more effective than placebo. The difference between the two products was not statistically significant, although the score for Mersyndol was somewhat better by both methods of study. The crossover data did not allow judgments concerning side effects in spite of its greater efficiency in quantifying pain relief.
本研究通过交叉设计与平行组设计比较了两种标准组合（阿司匹林可待因与美尔辛多）及安慰剂的镇痛效果。对三组12至13名交叉受试者进行了研究，将两次拔牙分为六个亚组，每组五至七名受试者，每个序列的镇痛结果在定性上相同，且在统计学上至少与每组38至42次拔牙的平行组分析结果一样显著。两种方法均显示，镇痛药在统计学上比安慰剂更有效。两种产品之间的差异无统计学意义，尽管通过两种研究方法，美尔辛多的评分都略高。尽管交叉设计在量化疼痛缓解方面效率更高，但该设计的数据无法对副作用进行判断。
