Tin L Y, Pitre M, Conly J M
Department of Pharmacy Services, Toronto Hospital, University of Toronto, Ontario, Canada.
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):135-40. doi: 10.1016/0732-8893(95)00091-n.
A retrospective analysis of the clinical and economic outcome of a regimen of cefotaxime 1 g given every 12 h was conducted following the introduction of an institutional policy recommending this new dosing strategy. Patients were identified from a log order entry in the pharmacy, and the medical records were reviewed using a standardized data collection form. Explicit criteria were applied for the indications for antimicrobial therapy, presence of infection, and outcome parameters. A total of 60 patients with a mean (+/- SD) age of 56.2 (+/- 17.8) years and a mean (+/- SD) length of stay of 20.75 (+/- 18.1) days were identified. Of these, 48 (80%) were found to have a clinically or microbiologically documented infection, and of the 42 patients who could be assessed accordingly to the criteria chosen, 37 (88%) had a favorable clinical response; 21 patients (35%) received cefotaxime alone. The costs for administration of cefotaxime have decreased by approximately 30% since the introduction of this new dosing regimen.
在引入一项推荐新给药策略（每12小时给予1克头孢噻肟）的机构政策后，对该治疗方案的临床和经济结果进行了回顾性分析。通过药房的医嘱录入记录确定患者，并使用标准化数据收集表对病历进行审查。对抗菌治疗指征、感染存在情况和结果参数应用了明确的标准。共确定了60例患者，平均（±标准差）年龄为56.2（±17.8）岁，平均（±标准差）住院时间为20.75（±18.1）天。其中，48例（80%）被发现有临床或微生物学记录的感染，在可根据所选标准进行评估的42例患者中，37例（88%）有良好的临床反应；21例患者（35%）仅接受了头孢噻肟治疗。自引入这种新的给药方案以来，头孢噻肟的给药成本下降了约30%。
