Bruch H P, Kujath P
Department of Surgery, University of Lübeck, Germany.
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):203-7. doi: 10.1016/0732-8893(95)00082-l.
A total of 548 patients with postoperative pneumonia were treated with 1 or 2 g cefotaxime twice daily. Of the 88 patients without serious underlying diseases who received the 1-g 12-h dosage regimen, all were considered to be clinically cured, and all 54 isolated pathogens were eradicated or presumed to be eradicated. In the group with severe infection or severe underlying disease receiving 2 g 12-h cefotaxime, the overall clinical success rate (cured plus improved) was 98.4%. Results from this study support the use of cefotaxime as an alternative to empiric monotherapy for nosocomial pneumonia in surgical-service patients who are not neutropenic or on long-term artificial ventilation.
共有548例术后肺炎患者接受了每日两次、每次1或2克头孢噻肟的治疗。在接受1克每12小时给药方案的88例无严重基础疾病的患者中，所有患者均被认为临床治愈，所有54株分离病原体均被根除或推测已被根除。在接受每12小时2克头孢噻肟治疗的严重感染或严重基础疾病组中，总体临床成功率（治愈加好转）为98.4%。本研究结果支持将头孢噻肟用作非中性粒细胞减少或未进行长期人工通气的外科手术患者医院获得性肺炎经验性单药治疗的替代药物。
