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每日两次头孢噻肟治疗住院严重感染患者的前瞻性评估

Prospective evaluation of twice-daily cefotaxime in the treatment of hospitalized patients with severe infections.

作者信息

Keller C

机构信息

Department of Lung and Bronchial Diseases, Nordwestkrankenhaus, Frankfurt, Germany.

出版信息

Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):159-61. doi: 10.1016/0732-8893(95)00084-n.

DOI:10.1016/0732-8893(95)00084-n
PMID:7587032
Abstract

Cefotaxime 2 g every 12 h was administered to adults with severe nosocomial pneumonia in a prospective noncomparative study. The results confirmed that this regimen is adequate and appropriate therapy for nosocomial pneumonia, with the combination of cefotaxime and an aminoglycoside reserved for cases where multiresistant, Gram-negative bacterial infections are strongly suspected.

摘要

在一项前瞻性非对照研究中,对患有严重医院获得性肺炎的成年人每12小时给予2克头孢噻肟。结果证实,该治疗方案是治疗医院获得性肺炎的充分且合适的疗法,头孢噻肟与氨基糖苷类药物联合使用仅用于高度怀疑多重耐药革兰氏阴性菌感染的病例。

相似文献

1
Prospective evaluation of twice-daily cefotaxime in the treatment of hospitalized patients with severe infections.每日两次头孢噻肟治疗住院严重感染患者的前瞻性评估
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):159-61. doi: 10.1016/0732-8893(95)00084-n.
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Cefotaxime versus ceftriaxone for the treatment of nosocomial pneumonia. Results of a multicenter study.
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):171-2. doi: 10.1016/0732-8893(95)00083-m.
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Study of cefotaxime twice daily for the therapy of postoperative pneumonia. The German Cefotaxime Study Group.头孢噻肟每日两次治疗术后肺炎的研究。德国头孢噻肟研究小组。
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):203-7. doi: 10.1016/0732-8893(95)00082-l.
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Nosocomial pneumonia: comparative multicentre trial between monotherapy with cefotaxime and treatment with antibiotic combinations.医院获得性肺炎:头孢噻肟单药治疗与抗生素联合治疗的多中心对照试验
Infection. 1991;19 Suppl 6:S320-5. doi: 10.1007/BF01715772.
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The choice of antibacterial drugs.抗菌药物的选择。
Med Lett Drugs Ther. 1998 Mar 27;40(1023):33-42.
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In nosocomial pneumonia, optimizing antibiotics other than aminoglycosides is a more important determinant of successful clinical outcome, and a better means of avoiding resistance.在医院获得性肺炎中,优化除氨基糖苷类以外的抗生素是临床成功结局更重要的决定因素,也是避免耐药性的更好方法。
Semin Respir Infect. 1997 Dec;12(4):278-93.
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[Treatment of severe infections: should one always administer an aminoglycoside?].[严重感染的治疗:是否总是应该使用氨基糖苷类药物?]
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[Amoxycillin/potassium clavulanate in inpatients with bronchopulmonary infections].[阿莫西林/克拉维酸钾用于支气管肺部感染住院患者]
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A retrospective analysis of twice-daily cefotaxime compared to conventional therapy for the treatment of infections in a USA hospital.一项关于在美国一家医院中,每日两次使用头孢噻肟与传统疗法治疗感染的回顾性分析。
Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):167-9. doi: 10.1016/0732-8893(95)00102-g.

引用本文的文献

1
Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections.头孢噻肟。对其抗菌活性和药代动力学特性的重新评估,以及对其每日两次给药治疗轻至中度感染时的治疗效果的综述。
Drugs. 1997 Mar;53(3):483-510. doi: 10.2165/00003495-199753030-00009.