Henriksen S J, Prospero-Garcia O, Phillips T R, Fox H S, Bloom F E, Elder J H
Department of Neuropharmacology, Scripps Research Institute, La Jolla, C 92037, USA.
Curr Top Microbiol Immunol. 1995;202:167-86. doi: 10.1007/978-3-642-79657-9_12.
Feline immunodeficiency virus infects the CNS and results in predictable pathophysiology strikingly similar to that seen with HIV-1 infection of humans. The observed pathophysiology is mimicked in several physiologically assessed modalities, further supporting the validity of the feline model. Peripheral and control evoked potential findings and the occurrence of the sleep architecture changes in both cat and human disease provide an intriguing focus for further investigation. Although structurally diverse in an absolute sense, FIV and HIV-1 share basic structural features and commonalities of their life cycle. It is likely that by understanding the common mechanisms by which these lentiviruses influence CNS function, a more complete understanding of the neurological deficits seen in HIV-1 infected patients will be obtained. The cat model is particularly valuable for study of CNS disease, since it allows detailed analyses of events during the acute phase of infection, under circumstances in which the nature and timing of the infection are carefully controlled. The availability of molecular clones for mutational analysis will facilitate mapping of genomic regions critical to the perturbation of CNS function. It is suggested that development of intervention strategies in the cat model will yield treatment modalities directly applicable to HIV-1 infection of humans.
猫免疫缺陷病毒感染中枢神经系统，导致可预测的病理生理过程，与人类感染HIV-1时所见的病理生理过程极为相似。在多种生理评估方式中都观察到了类似的病理生理过程，这进一步支持了猫模型的有效性。猫和人类疾病中周围和对照诱发电位的发现以及睡眠结构变化的发生，为进一步研究提供了一个有趣的焦点。尽管从绝对意义上讲，猫免疫缺陷病毒和HIV-1在结构上存在差异，但它们具有共同的基本结构特征和生命周期共性。通过了解这些慢病毒影响中枢神经系统功能的共同机制，有可能更全面地理解HIV-1感染患者出现的神经功能缺损。猫模型对于研究中枢神经系统疾病特别有价值，因为它允许在感染的急性期对事件进行详细分析，且感染的性质和时间是经过仔细控制的。用于突变分析的分子克隆的可得性将有助于绘制对中枢神经系统功能扰动至关重要的基因组区域。有人认为，在猫模型中开发干预策略将产生直接适用于人类HIV-1感染的治疗方式。
