小鼠基因位点中的八个新的多态微卫星

Eight new polymorphic microsatellites in mouse gene loci.

作者信息

Santos J, Pérez de Castro I, Herranz M, Fernández-Piqueras J

机构信息

Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.

出版信息

Cytogenet Cell Genet. 1995;71(3):223-4. doi: 10.1159/000134114.

DOI:10.1159/000134114

PMID:7587381

Abstract

Eight mouse gene loci (Atp1b2, Epo, Kit, Krt2, Mor1, Ren1, Pdgfb, and Wnt1) that contain unidentified microsatellites were selected to detect simple sequence-length polymorphisms on genomic DNAs from two laboratory strains (C57BL/6J and RF/J) and strains recently derived from the Mus musculus species complex (CAST/Ei, MOLF/Ei, CZECH II, and M. m. domesticus) and from M. spretus (SPRET/Ei). All microsatellite DNA sequences varied in size among some of the seven mouse strains tested. These new polymorphisms might be useful in the search for tumor suppressor genes involved in specific cancers.

摘要

选择了八个含有未鉴定微卫星的小鼠基因位点（Atp1b2、Epo、Kit、Krt2、Mor1、Ren1、Pdgfb和Wnt1），以检测来自两个实验室品系（C57BL/6J和RF/J）、最近从小家鼠物种复合体衍生而来的品系（CAST/Ei、MOLF/Ei、CZECH II和小家鼠）以及来自西班牙小鼠（SPRET/Ei）的基因组DNA上的简单序列长度多态性。在测试的七个小鼠品系中的一些品系中，所有微卫星DNA序列的大小都有所不同。这些新的多态性可能有助于寻找参与特定癌症的肿瘤抑制基因。