Mohr V D, Schmitt B, Göller T, Lenz J
Abteilung Chirurgie, Bundeswehrzentralkrankenhaus Koblenz.
Chirurg. 1995 Aug;66(8):818-22.
Thoracic actinomycosis is a rare disease without characteristic clinical signs. Approximately 90% of patients suffering from thoracic actinomycosis have undergone diagnostic and therapeutic procedures based on a wrong diagnostic hypothesis (malignancies 35-44%, other pulmonary disorders 33-35%). The opportunities for a timely and adequate diagnosis by the use of clinical examination, laboratory studies, microbiology studies, radiologic imaging or invasive measures are limited. In 85%, thoracic actinomycosis has not been identified prior to thoracotomy, open biopsy and histological examination. Based on a wrong diagnostic hypothesis, resective thoracic surgery according to the principles of oncologic surgery can hardly be avoided. We report on a 43-year-old male suffering from actinomycosis of the left hemithorax. Clinical signs, differential diagnosis, treatment and clinical course are described. The role of surgery in the treatment protocol of thoracic actinomycosis is discussed. In pulmonary and pleural disorders of unknown origin, differential diagnosis should include thoracic actinomycosis as early as possible. Due to the considerably high mortality rate of untreated disease, the outcome of thoracic actinomycosis can only be improved by a timely and combined employment of surgical and antibiotic therapy.
胸段放线菌病是一种罕见疾病,无特征性临床症状。约90%的胸段放线菌病患者基于错误的诊断假设接受了诊断和治疗程序(恶性肿瘤占35 - 44%,其他肺部疾病占33 - 35%)。通过临床检查、实验室研究、微生物学研究、放射影像学或侵入性措施进行及时、充分诊断的机会有限。85%的病例在开胸手术、开放性活检和组织学检查之前未被确诊。基于错误的诊断假设,很难避免按照肿瘤外科原则进行的切除性胸外科手术。我们报告一例43岁男性左半胸放线菌病患者。描述了其临床症状、鉴别诊断、治疗及临床病程。讨论了手术在胸段放线菌病治疗方案中的作用。在不明原因的肺部和胸膜疾病中应尽早将胸段放线菌病纳入鉴别诊断。由于未治疗疾病的死亡率相当高,只有通过及时联合应用手术和抗生素治疗才能改善胸段放线菌病的治疗效果。