Zhang L, Zhao L, Ma J
Beijing Institute for Cancer Research.
Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Jul;29(4):198-201.
Serum micronutrient levels and their relationship to precancerous gastric lesions were studied in 600 subjects aged 35-64 years living in high-risk area of gastric cancer in Linqu County, Shandong Province. Serum micronutrient levels in local residents were 0.54 micrograms/ml, 0.29 micrograms/ml, 3.14 micrograms/ml, 9.62 micrograms/ml, 30.2 micrograms/L, 924 micrograms/L, 1 016 micrograms/L, and 42.0 micrograms/L for vitamin A, beta-carotene, vitamin C, vitamin E, selenium, zinc, copper and ferritin, respectively. Serum levels of beta-carotene, vitamin C and ferritin, and ratio of serum levels of zinc and copper correlated inversely to severity of pathological changes in gastric mucous membrane. With increase of serum level of beta-carotene or vitamin C, odds ratios (OR) of intestinal dysplasia and metaplasia lowered to 0.8, 0.6 and 0.9, 0.5, respectively, and with increase of those of both beta-carotene and vitamin C, their OR lowered further to 0.16, with patients of chronically atrophic gastritis as controls. It indicated maybe beta-carotene and vitamin C played a strong contributing role in protecting from development of precancerous gastric lesions.
对山东省临朐县胃癌高发区600名35 - 64岁的受试者进行了血清微量营养素水平及其与胃癌前病变关系的研究。当地居民血清中维生素A、β - 胡萝卜素、维生素C、维生素E、硒、锌、铜和铁蛋白的水平分别为0.54微克/毫升、0.29微克/毫升、3.14微克/毫升、9.62微克/毫升、30.2微克/升、924微克/升、1016微克/升和42.0微克/升。血清β - 胡萝卜素、维生素C和铁蛋白水平以及血清锌与铜的比值与胃黏膜病理变化的严重程度呈负相关。以慢性萎缩性胃炎患者为对照，随着血清β - 胡萝卜素或维生素C水平的升高，肠化生和异型增生的比值比（OR）分别降至0.8、0.6和0.9、0.5，而当β - 胡萝卜素和维生素C水平均升高时，其OR进一步降至0.16。这表明β - 胡萝卜素和维生素C可能在预防胃癌前病变的发生中发挥了重要作用。
