Pickup J C, Mattock M B, Crook M A, Chusney G D, Burt D, Fitzgerald A P
Division of Chemical Pathology, United Medical School of Guy's Hospital, London, UK.
Diabetes Care. 1995 Aug;18(8):1100-3. doi: 10.2337/diacare.18.8.1100.
OBJECTIVE--To examine the association between serum sialic acid concentrations and coronary heart disease (CHD) in a cross-sectional study of non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--NIDDM patients (n = 145) attending a diabetic clinic were studied. CHD status was assessed by questionnaire and electrocardiogram coding, and potential risk factor assessment included measurement of fasting serum lipid and lipoprotein concentrations, blood pressure, and urinary albumin excretion rate (AER). RESULTS--Male NIDDM patients with CHD had a higher serum sialic acid level than those without CHD: 2.56 (2.24, 2.72) mmol/l vs. 2.24 (2.18, 2.30) mmol/l, P = 0.01, mean (95% confidence interval). They were also older, had a longer duration of diabetes, had a higher AER, had higher total triglyceride, very-low-density lipoprotein triglyceride and cholesterol, and lipoprotein(a) concentrations, and had a lower apolipoprotein A1 concentration. In an age adjusted multiple lipoprotein(a), hypercholesterolemia, and hypertension were associated with CHD. In women, only hypertension treatment was associated with CHD. CONCLUSIONS--There is a strong univariate association between elevated serum sialic acid and CHD in men (but not women) with NIDDM.
目的——在一项非胰岛素依赖型糖尿病（NIDDM）的横断面研究中，检测血清唾液酸浓度与冠心病（CHD）之间的关联。研究设计与方法——对就诊于糖尿病门诊的145例NIDDM患者进行研究。通过问卷调查和心电图编码评估冠心病状态，潜在危险因素评估包括测量空腹血清脂质和脂蛋白浓度、血压以及尿白蛋白排泄率（AER）。结果——患有冠心病的男性NIDDM患者血清唾液酸水平高于未患冠心病者：2.56（2.24，2.72）mmol/L对2.24（2.18，2.30）mmol/L，P = 0.01，均值（95%置信区间）。他们年龄更大，糖尿病病程更长，AER更高，总甘油三酯、极低密度脂蛋白甘油三酯和胆固醇以及脂蛋白（a）浓度更高，而载脂蛋白A1浓度更低。在年龄校正后的多因素分析中，脂蛋白（a）升高、高胆固醇血症和高血压与冠心病相关。在女性中，只有高血压治疗与冠心病相关。结论——在患有NIDDM的男性（而非女性）中，血清唾液酸升高与冠心病之间存在很强的单因素关联。
