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[多杀巴斯德菌感染所致间质性肺炎和败血症]

[Interstitial pneumonia and sepsis due to a Pasteurella multocida infection].

作者信息

Schlichthaar H, Rohrer T, Schuster G, Lehnert H

机构信息

Klinik für Endokrinologie und Stoffwechselkrankheiten, Universität Magdeburg.

出版信息

Dtsch Med Wochenschr. 1995 Nov 17;120(46):1582-6. doi: 10.1055/s-2008-1055516.

DOI:10.1055/s-2008-1055516
PMID:7588039
Abstract

HISTORY AND CLINICAL FINDINGS

A 65-year-old diabetic (requiring insulin during the last year) was admitted as an emergency because of a septic temperature rising to 40 degrees C with rigor, tachycardia (up to 120/min) and dyspnoea. On examination there was local reddening and swelling of the skin over the right thenar eminence and along the lower arm. Two days before admission a bad scratch had been inflicted on his right hand by a cat. He had first noticed the reddening and swelling 10 hours after the incident; 1 1/2 days after the scratch and 9-10 hours before hospitalization the first bouts of fever had occurred.

EXAMINATIONS

The chest radiogram showed interstitial pneumonia. The clinical findings, the laboratory tests (white cell count 21 750/microliters, platelets 140,000/microliters, C-reactive protein 35 mg/l and positive blood cultures pointed to early septicaemia. The germ was identified as Pasteurella multocida two days after blood had been taken for culturing. HbA1c was 11.38%.

TREATMENT AND COURSE

From the time of hospitalization the patient had been treated with ceftriaxon, 2 g daily intravenously, and also with erythromycin because atypical pneumonia had been the suspected diagnosis at first and acute chlamydia infection had at first not been excluded. The patient's general condition quickly improved and the fever started to go down a few hours after onset of treatment. Blood cultures became negative after the first administration of antibiotics. He was discharged in a good state on optimal insulin dosage.

CONCLUSION

Pasteurella multocida is present in a high percentage of domestic animals and can be the cause of systemic infections in immunocompromised patients (e. g. poorly controlled diabetes mellitus).

摘要

病史与临床发现

一名65岁糖尿病患者(去年开始需注射胰岛素)因败血症紧急入院,体温升至40摄氏度,伴有寒战、心动过速(最高达120次/分钟)及呼吸困难。检查发现右手大鱼际肌及下臂皮肤局部发红、肿胀。入院前两天,其右手被猫抓伤。抓伤后10小时他首次注意到发红和肿胀;抓伤后1.5天,即住院前9 - 10小时,首次出现发热。

检查

胸部X光片显示间质性肺炎。临床症状、实验室检查(白细胞计数21750/微升,血小板140000/微升,C反应蛋白35毫克/升,血培养阳性)提示早期败血症。采血培养两天后,病菌被鉴定为多杀巴斯德菌。糖化血红蛋白(HbA1c)为11.38%。

治疗与病程

自住院起,患者接受头孢曲松治疗,每日静脉注射2克,同时还使用了红霉素,因为起初怀疑是非典型肺炎,且最初未排除急性衣原体感染。患者的一般状况迅速改善,治疗开始后数小时体温开始下降。首次使用抗生素后血培养转阴。患者出院时状态良好,胰岛素用量达到最佳水平。

结论

多杀巴斯德菌在很大比例的家畜中存在,可导致免疫功能低下患者(如糖尿病控制不佳者)发生全身感染。

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