Shukla H S, Hughes L E, Gravelle I H, Satir A
Ann Surg. 1979 Jan;189(1):53-7. doi: 10.1097/00000658-197901000-00011.
Mammary skin edema has been quantitated in 205 cases of T1, T2 and T3 breast cancer by mammographic measurement, and its prognostic significance assessed. Edema was present in 70% of patients and the incidence was directly related to tumor size. Edema was seen on occasions in all quadrants of the breast, but the inner and lower quadrants were the most frequent sites of edema irrespective of the site of tumor. Histology showed the skin thickening located in the reticular dermis; the papillary dermis and epidermis showed no change. It was shown that neither dermal lymphatic involvement nor lymphatic obstruction by regional node involvement was of primary etiological significance. Skin edema correlates with prognosis since there is an increased likelihood of both systemic and local recurrence if skin edema exceeds 0.5 mm. Further investigation and longer follow-up is necessary to show whether skin edema represents a parameter which carries prognostic significance independent of the more usual clinical indications.
通过乳房X线测量对205例T1、T2和T3期乳腺癌患者的乳腺皮肤水肿进行了定量分析，并评估了其预后意义。70%的患者存在水肿，且发病率与肿瘤大小直接相关。乳房的所有象限都偶尔可见水肿，但无论肿瘤位于何处，内下象限都是水肿最常见的部位。组织学检查显示皮肤增厚位于网状真皮层；乳头真皮层和表皮无变化。结果表明，真皮淋巴管受累或区域淋巴结受累导致的淋巴管阻塞均无原发性病因学意义。皮肤水肿与预后相关，因为如果皮肤水肿超过0.5毫米，全身和局部复发的可能性都会增加。需要进一步研究和更长时间的随访，以确定皮肤水肿是否代表一个独立于更常见临床指标的具有预后意义的参数。
