Necas E, Sefc L, Brecher G, Bookstein N
Department of Pathophysiology, First Medical Faculty, Charles University, Prague, Czech Republic.
Exp Hematol. 1995 Nov;23(12):1242-6.
Using quantitative data available from the literature on murine hematopoiesis, the functional reserve of multipotential stem cells was calculated by comparing daily blood cell production with the potential of clonogenic spleen colony-forming cells (CFU-S) to generate blood cells. The potential of the day-8 CFU-S (CFU-S-8) population is estimated to be from 4000 to 37,000 times greater than needed in steady-state hematopoiesis. The CFU-S population may thus serve to provide a functional reserve to supply large numbers of peripheral blood cells via committed lineage-specific cells within days, whenever needed.
利用从有关小鼠造血的文献中获得的定量数据，通过比较每日血细胞生成量与克隆性脾集落形成细胞（CFU-S）产生血细胞的潜力，计算了多能干细胞的功能储备。估计第8天CFU-S（CFU-S-8）群体的潜力比稳态造血所需的潜力大4000至37000倍。因此，CFU-S群体可用于提供功能储备，以便在需要时通过定向谱系特异性细胞在数天内供应大量外周血细胞。
