印记基因H19和IGF-2在人膀胱癌中的表达。
The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma.
作者信息
Elkin M, Shevelev A, Schulze E, Tykocinsky M, Cooper M, Ariel I, Pode D, Kopf E, de Groot N, Hochberg A
机构信息
Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel.
出版信息
FEBS Lett. 1995 Oct 23;374(1):57-61. doi: 10.1016/0014-5793(95)01074-o.
The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.
印记基因H19在人类胚胎、胎儿组织中高度表达，而在成人中几乎完全关闭。然而，它在包括膀胱癌在内的多种肿瘤中重新表达，表明H19 RNA是一种癌胚RNA。与注射前的细胞相比，注射膀胱癌细胞系诱导的肿瘤表达H19。这些观察结果支持了H19表达与膀胱癌之间存在正相关的观点。在人类膀胱癌样本中观察到H19和IGF-2的印记缺失。
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