Tulppala M, Viinikka L, Ylikorkala O
Department I of Obstetrics and Gynecology Children's Hospital, University Central Hospital of Helsinki, Finland.
Fertil Steril. 1992 Jun;57(6):1216-9. doi: 10.1016/s0015-0282(16)55076-6.
To see if changes in prostacyclin and thromboxane A2 (TXA2) production during early pregnancy in women with habitual abortion is a pregnancy-induced change, we compared the production of these prostanoids in habitual aborters and in healthy controls in nonpregnant state and related it to luteal function.
Comparison between patients (n = 16) with a history of at least three consecutive miscarriages and healthy controls without a history of abortions (n = 11).
Departments I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland.
Habitual aborters and control women exhibited no change in the urinary output of the stable degradation products of prostacyclin and TXA2 when studied between 0 and 2 and 5 and 8 days after the luteinizing hormone peak. Habitual aborters as a whole, or when subgrouped to those with normal (10 cycles) or defective luteal function (12 cycles) did not differ from the control series with regard to prostacyclin and TXA2 production.
Productions of prostacyclin and TXA2 are not relative to the luteal function and are normal in nonpregnant women with a history of habitual abortion.
为了探究习惯性流产女性在妊娠早期前列环素和血栓素A2（TXA2）生成的变化是否为妊娠诱导的改变，我们比较了习惯性流产者和非妊娠状态下健康对照者这些类前列腺素的生成情况，并将其与黄体功能相关联。
对有至少连续三次流产史的患者（n = 16）和无流产史的健康对照者（n = 11）进行比较。
芬兰赫尔辛基大学中心医院妇产科第一和第二科室。
在黄体生成素峰后的0至2天以及5至8天进行研究时，习惯性流产者和对照女性的前列环素和TXA2稳定降解产物的尿量均无变化。总体而言，习惯性流产者，或分为黄体功能正常（10个周期）或黄体功能不全（12个周期）的亚组时，在前列环素和TXA2生成方面与对照组并无差异。
前列环素和TXA2的生成与黄体功能无关，且在有习惯性流产史的非妊娠女性中是正常的。
