Melis G B, Paoletti A M, Ajossa S, Guerriero S, Depau G F, Mais V
Department of Obstetrics and Gynecology, University of Cagliari, Italy.
Fertil Steril. 1995 Dec;64(6):1088-93. doi: 10.1016/s0015-0282(16)57965-5.
To assess if ovulation induction with gonadotropins alone is an appropriate treatment in couples affected by unexplained and mild male factor-related infertility and if the concomitant IUI improves the pregnancy rate (PR).
Prospective and randomized trial.
Infertility Centre of Department of Obstetrics and Gynecology of the University of Cagliari, Cagliari, Italy.
Two hundred couples affected by unexplained or mild male factor-related infertility were assigned randomly to one of two treatment groups: group A (n = 100), treated with three consecutive cycles of ovulation induction with gonadotropins associated with timed vaginal intercourse; group B (n = 100), treated with three consecutive cycles of ovulation induction with gonadotropins associated with IUI.
Pregnancy rate.
The PRs obtained with ovulation induction with gonadotropins associated with IUI were similar to those obtained with ovulation induction with gonadotropins associated with timed vaginal intercourse.
Ovulation induction with gonadotropins alone may be as effective as ovulation induction with gonadotropins associated with IUI in couples with unexplained and mild male factor infertility and can represent the initial treatment option for its minimal invasivity and reduced cost and organizational problems.
评估单独使用促性腺激素诱导排卵对不明原因及轻度男性因素相关不孕症夫妇是否为合适的治疗方法，以及同时进行宫腔内人工授精（IUI）是否能提高妊娠率（PR）。
前瞻性随机试验。
意大利卡利亚里大学妇产科不孕症中心。
200对不明原因或轻度男性因素相关不孕症夫妇被随机分配到两个治疗组之一：A组（n = 100），接受连续三个周期的促性腺激素诱导排卵并配合定时阴道性交治疗；B组（n = 100），接受连续三个周期的促性腺激素诱导排卵并配合IUI治疗。
妊娠率。
促性腺激素诱导排卵配合IUI获得的妊娠率与促性腺激素诱导排卵配合定时阴道性交获得的妊娠率相似。
对于不明原因及轻度男性因素不孕症夫妇，单独使用促性腺激素诱导排卵可能与促性腺激素诱导排卵配合IUI一样有效，且因其微创性、成本降低及组织问题减少，可作为初始治疗选择。
