Gregoriou O, Vitoratos N, Papadias C, Konidaris S, Gargaropoulos A, Rizos D
2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Eur J Obstet Gynecol Reprod Biol. 1996 Feb;64(2):213-6. doi: 10.1016/0301-2115(95)02280-5.
To compare the pregnancy rates achieved by intrauterine insemination or timed intercourse in gonadotrophin stimulated cycles in couples whose only detectable abnormality was poor sperm quality.
Sixty-two couples with primary or secondary infertility due to male factor entered the study. The 62 couples were randomly equally divided into two groups. Each group began one of the two treatment modalities (controlled ovarian hyperstimulation in conjunction with timed intercourse or intrauterine insemination) for three consecutive cycles and then switched to the alternative treatment after one rest cycle, if pregnancy was not achieved.
Five pregnancies (3.9%) were achieved after 128 cycles with timed intercourse and 15 pregnancies (11.5%) after 130 cycles with intrauterine insemination. The difference was found to be statistically significant (P < 0.05).
We suggest that intrauterine insemination during hMG stimulated cycles improves the pregnancy rates of couples whose only detectable abnormality is poor sperm quality.
比较在仅可检测到精子质量差这一异常情况的夫妇中，在促性腺激素刺激周期内通过宫腔内人工授精或定时性交所达到的妊娠率。
62对因男性因素导致原发性或继发性不孕的夫妇进入该研究。这62对夫妇被随机等分为两组。每组开始两种治疗方式之一（控制性卵巢过度刺激联合定时性交或宫腔内人工授精），连续进行三个周期，若未妊娠，则在一个休息周期后改用另一种治疗方式。
定时性交128个周期后有5例妊娠（3.9%），宫腔内人工授精130个周期后有15例妊娠（11.5%）。发现差异具有统计学意义（P < 0.05）。
我们建议，在人绝经期促性腺激素刺激周期内进行宫腔内人工授精可提高仅可检测到精子质量差这一异常情况的夫妇的妊娠率。
