Aono T, Sakaguchi T, Tsukada K, Fujita N, Ishiduka D, Hatakeyama K
First Department of Surgery, Niigata University School of Medicine, Japan.
J Int Med Res. 1995 Jul-Aug;23(4):299-307. doi: 10.1177/030006059502300411.
The plasma disappearance rate of indocyanine green was examined after prostaglandin E1 administration in 11 patients with chronic liver disease. The patients were divided into two groups according to the presence (n = 6) or absence (n = 5) of liver cirrhosis. Indocyanine green (0.1 mg/kg) was introduced as an intravenous bolus 5 min after prostaglandin E1 administration and the disappearance rate of indocyanine green (ICG-K) was determined by a finger-monitoring method. Saline was injected as the control. Prostaglandin E1 administration increased ICG-K, and this response was dose dependent when the prostaglandin E1 dose ranged from 0.01 to 0.05 micrograms/kg/min. When ICG-K after prostaglandin E1 relative to the ICG-K after saline (the control) was defined as the ICG-K ratio, the ICG-K ratio in the liver cirrhosis group was higher than that in the group without cirrhosis. These findings suggest that prostaglandin E1 increases the ICG-K of patients with chronic liver disease, and that this is strongest in patients with liver cirrhosis.
在11例慢性肝病患者中，静脉注射前列腺素E1后检测了吲哚菁绿的血浆消失率。根据是否存在肝硬化将患者分为两组，其中有肝硬化组6例，无肝硬化组5例。在注射前列腺素E1 5分钟后，静脉推注吲哚菁绿（0.1mg/kg），采用手指监测法测定吲哚菁绿的消失率（ICG-K），注射生理盐水作为对照。注射前列腺素E1可使ICG-K升高，当前列腺素E1剂量在0.01至0.05微克/千克/分钟范围内时，这种反应呈剂量依赖性。将前列腺素E1注射后的ICG-K相对于生理盐水（对照）注射后的ICG-K定义为ICG-K比值，肝硬化组的ICG-K比值高于无肝硬化组。这些结果表明，前列腺素E1可使慢性肝病患者的ICG-K升高，且在肝硬化患者中这种作用最强。
