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Omental delivery of prostaglandin E1 effectively increases portal venous blood flow in 66%-hepatectomized rats.

作者信息

Aono T, Sakaguchi T, Fujita N, Shimizu T, Tsukada K, Hatakeyama K

机构信息

Department of Surgery, Niigata University School of Medicine, Japan.

出版信息

Surg Today. 1997;27(5):473-6. doi: 10.1007/BF02385718.

DOI:10.1007/BF02385718
PMID:9130357
Abstract

Changes in portal venous blood flow (PVF) and systemic arterial blood pressure (SAP) were examined following prostaglandin E1 (PGE) application to the greater omentum and femoral vein in 66%-hepatectomized rats. PVF increased when PGE was administered to the omentum and femoral vein at 7.5 micrograms/kg per min for 2 min. The magnitude of PVF response due to both administrations was dose-dependent, but the duration of the PVF response in the omental application was longer than that in the femoral administration. SAP was unchanged after omental application, while femoral administration reduced SAP concomitant with an increase in PVF. These results suggest that, in this hepatectomized model, the omentum is a better site for PGE administration than the vein, and that omental PGE delivery is also effective for enhancing PVF without inducing any changes in SAP.

摘要

相似文献

1
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Surg Today. 1997;27(5):473-6. doi: 10.1007/BF02385718.
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A pharmacological analysis of prostaglandin E1 on portal blood flow after partial hepatectomy in rats.前列腺素E1对大鼠部分肝切除术后门静脉血流的药理学分析。
Surg Today. 1993;23(3):277-9. doi: 10.1007/BF00309242.
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Enhanced hepatic portal blood flow induced by prostaglandin E1 following liver transplantation in pigs.猪肝脏移植后前列腺素E1诱导的肝门静脉血流增加。
Surg Today. 1994;24(7):621-6. doi: 10.1007/BF01833727.
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Insulinopenia as a risk factor in hepatectomy and its resolution by intraportal insulin administration.胰岛素缺乏作为肝切除术中的一个危险因素及其通过门静脉内注射胰岛素得以解决。
Am J Surg. 1991 Jul;162(1):43-9. doi: 10.1016/0002-9610(91)90200-w.
10
Prostaglandin E1 enhances hepatic portal venous flow by dilating the portal vascular bed in 70% hepatectomized dog.前列腺素E1通过扩张70%肝切除犬的门静脉血管床来增强肝门静脉血流。
Gastroenterol Jpn. 1992 Jun;27(3):341-7. doi: 10.1007/BF02777752.